Articles

We would like to share with you the extensive experience of one of distributor through the words of Vincenzo Iezzi. In this short interview Vincenzo describes the main features of Cogiton, our clinically tested and patented food supplement for the central nervous system health.

What is oxidative stress, causes, effects on brain and central nervous system and how to protect them.

The protection of brain and central nervous system from oxidative stress requires specific, synergic and harmonic supplementation of ingredients able to concurrently address the main aspects of cerebral OS.

As a continuation (see Episode 1) of our journey with Prof. Gabriele Costantino on “Challenges in Oxidative Homeostasis and Supplementation” we would like to share with you the second episode.

We had the pleasure to discuss with Prof. Costantino about oxidative stress, its role in physiological and pathological conditions, antioxidant defenses and RedOx balance.

In this chapter we present the first episode of Prof. Costantino’s point of view on these topics, as a part of an article, which will be fully published in two episodes.

Experimental evidences link aging and cognitive decline to oxidative stress damages.

Today there are numerous natural substances for which the European Food Safety Authority (EFSA) has recognised antioxidant potential, and the ability to use these substances in the right way, amount and combination may represent an added value in the development of innovative food supplements able to modulate the RedOx state in the central nervous system

Increased reactive oxygen species (ROS) levels induce alteration of the vascular structures and functions through inflammation, cell proliferation and migration, apoptosis, and extracellular matrix alteration. Several experimental evidences support the presence of an oxidative stress component in hypertension and atherosclerotic diseases. Indeed, a tight connection between oxidative stress and endothelial disfunction has been observed in hypertensive subjects.

Living organisms developed complex antioxidant mechanisms to protect themselves from potential damage of oxidizing species, such as reactive oxygen species (ROS), and almost all organisms control free radical levels by a fine equilibrium, namely RedOx balance. The harmful effects of elevated ROS levels can be counteracted by several antioxidant enzymes and substances.

Nutrition covers a key role in human health and the concepts of food and diet have largely evolved over human history. Nutrition was originally characterized by food availability and represented mostly an action to address basic nutritional needs and ensure individual survival. Nowadays, nutrition has largely evolved from such basic concepts. 

Oxidative Stress (OS) is a condition due to unbalanced RedOx state of the organism, and several high impact factor journals (Nature Review, Science and Science Translational Medicine) reported comprehensive reviews about the pathophysiological role of RedOx signalling in central homeostatic mechanisms at different levels.