Metabolic System
Oxidative Stress & Endothelial Dysfunctions
Increased reactive oxygen species (ROS) levels induce alteration of the vascular structures and functions through inflammation, cell proliferation and migration, apoptosis, and extracellular matrix alteration. Several experimental evidences support the presence of an oxidative stress component in hypertension and atherosclerotic diseases. Indeed, a tight connection between oxidative stress and endothelial disfunction has been observed in hypertensive subjects.
Physiological Modulation
Oxidative Stress (OS) is a condition due to unbalanced RedOx state of the organism, and several high impact factor journals (Nature Review, Science and Science Translational Medicine) reported comprehensive reviews about the pathophysiological role of RedOx signalling in central homeostatic mechanisms at different levels.