Management of Brain Oxidative Stress

Experimental evidences link aging and cognitive decline to oxidative stress damages.^1–4 

Central Nervous System (CNS) and in particular the brain are characterized by distinct features that make them highly sensitive to Oxidative Stress and micronutrient deficiencies. CNS is one of the systems with the highest oxygen consumption, the highest content of poly-unsaturated fatty acids that are highly sensitive to lipoperoxidation processes and the highest content of RedOX-active metal (Iron, Copper, etcc..). 

The connection between non-communicable human diseases (Chronic Diseases, such as Alzheimer and Parkinson’s Diseases)^1-4 and oxidative stress is now well-established and numerous actions have been taken to promote the development of new strategies that can support classical therapeutic approaches. 

Today there are numerous natural substances for which the European Food Safety Authority (EFSA) has recognised antioxidant potential,⁵ and the ability to use these substances in the right way, amount and combination may represent an added value in the development of innovative food supplements able to modulate the RedOx state in the central nervous system. 

It is following this novel line of research that Cor.Con. International is paving the way for the innovative food supplements of the future. Our innovative food supplements are patented and tested in clinical studies. The use of specific ingredients promotes the normal function of the nervous system, protects the cells from oxidative stress, promotes the normal psychological function, the normal cysteine synthesis, and the normal homocysteine metabolism.

From design, to patenting, to market distribution Cor.Con. International rationally developed products that aim at preserving and/or restoring the proper RedOx status and micronutrient content by enhancing what naturally happens during nutrition.  

References

1.           Hwang, O. Role of Oxidative Stress in Parkinson’s Disease. Exp. Neurobiol. 22, 11–17 (2013).

2.           Sies, H. & Jones, D. P. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat. Rev. Mol. Cell Biol.21, 363–383 (2020).

3.           Poprac, P. et al. Targeting Free Radicals in Oxidative Stress-Related Human Diseases. Trends Pharmacol. Sci. 38, 592–607 (2017).

4.           Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P. & Zuo, L. Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications. Oxidative Medicine and Cellular Longevity (2017).

5. https://ec.europa.eu/food/safety/labelling-and-nutrition/nutrition-and-health-claims_en