Afragil is a food supplement for the Gynecological health. Effective on oxidative stress and menopause symptoms.

Afragil is a food supplement based on a specific and harmonized combination of Calcium, Vit. D3, vitamin C, Lycopene from Solanum Lycopersicum, Astaxanthin from Haematococcus pluvialis, Bioflavonoids from Citrus Sinensis.

Afragil is available in chewable tablets; it is recommended to take one tablet per day.


Claims and Safety

It contributes to normal energy-yielding metabolism, to normal neurotransmission (Calcium), to the maintenance of normal muscle function, to the maintenance of normal bones, to normal blood calcium levels and to normal absorption/utilisation of calcium and phosphorus (Vit. D3) and to the protection of the cells from oxidative stress (Vit. C).*

It contributes to the protection of the cells from oxidative stress (Solanum Lycopersicum, Haematococcus pluvialis).**

*EFSA Claim as defined by the EU Regulation 1924/2006
**Botanical Claims as described in the Annex I of the Italian ministerial decree 10 August 2018(BELFRIT)

The product is safe and conforms to Directive 2002/46/EC.

The recommended daily dose should not be exceeded. Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Keep away from children below 3 years old.

Scientific Background

Menopause is the permanent cessation of menstruation due to the loss of ovarian and follicular activities. This leads to a significant hormonal unbalance, indeed, the main therapy for the menopause is hormone replacement therapy. A significantly increase in oxidative stress levels is observed during the perimenopause period (climacteric status), which is a menopausal transition period, when clinical features begin. Moreover, an increase in oxidative stress is also observed during hormone replacement therapy.

Both menopause/perimenopause and hormone replacement therapy induce an imbalance in the RedOx state of women that leads to the appearance of symptoms which have an impact on the women’s quality of life. There are several natural substances able to counteract OS harmful effects in women, but they have to be specifically and harmonically combined in order to be effective.

Clinical Studies

Thanks to its content in Lycopene from Solanum Lycopersicum and Astaxanthine from Haematococcus pluvialis it has beneficial effects in protecting cells from oxidative stress and relieving symptoms characterized by oxidative stress-related aspects in healthy women.

Panminerva Med. 2010;52(Suppl. 1 to No. 2):1-6

Many women spend almost one third of their lives in menopause. Shortly before menopause, when clinical features start to manifest, a menopausal transition period, namely perimenopause, takes place. An increase in oxidative stress (OS) levels is observed during the perimenopause period (climacteric status) and menopause. During this period of time there are many symptoms which have an impact on the women’s quality of life. Currently, there is gap in the treatment of climacteric and menopausal symptoms, and several new approaches are emerging, such as the use of natural substances able to mitigate the clinical manifestation of perimenopause period (climacteric status) and menopause.

There are several natural substances able to counteract OS harmful effects in women, and a specific, synergic and harmonic formula is required to concurrently address the main aspects of OS. To identify which pool of antioxidants have to be supplemented with the diet is a relevant aspect, since inappropriate supplementation can result in damages or inefficacy.

Properties and Indications

Afragil is a clinically tested food supplement characterized by a unique formulation based on ingredients endowed with antioxidant action specific for the management of women during perimenopause and menopause periods. Calcium supports the normal neurotransmission and contributes to the muscle functions. Synergically, Calcium and Vitamin D3 contribute to the maintenance of normal bones and to normal absorption/utilisation of calcium and phosphorus. Vitamin C protects the cells from oxidative stress.*

The presence of Solanum Lycopersicum and  Haematococcus pluvials  support the antioxidant action of Vitamin C.**

*EFSA Claim as defined by the EU Regulation 1924/2006
**Botanical Claims as described in the Annex I of the Italian ministerial decree 10 August 2018(BELFRIT)

Ingredients

  • Calcium Carbonate
  • Calcium Lactate
  • Bioflavonoids from Citrus Sinensis
  • Solanum Lycopersicum
  • Vitamin C
  • Vitamin D3
  • Haematococcus pluvials

Recommended Use

Afragil is available in chewable tablets; it is recommended to take one tablet per day.

Instructions

The recommended daily dose should not be exceeded. Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Keep away from children below 3 years old.

Gynecological supplements